Early life stress and novelty seeking behavior in adolescent monkeys
نویسندگان
چکیده
منابع مشابه
Early life stress and novelty seeking behavior in adolescent monkeys.
Recent evidence suggests that early exposure to mild stress promotes the development of novelty seeking behavior. Here we test this hypothesis in squirrel monkeys and investigate whether novelty seeking behavior is associated with differences in cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA), the dopamine metabolite homovanillic acid (HVA), the n...
متن کاملIn vivo MRS study of adolescent rhesus monkeys with early life stress experience
Introduction: Early life stress (ELS) is a major risk factor in the development of anxiety, conduct, and mood disorders and other behavioral problems in children and adults. Nonhuman primates are ideal model for investigating the behavioral consequences of ELS in humans and the underlying neural mechanisms. In vivo Magnetic Resonance Spectroscopy (MRS) provides a non-invasive approach to detect...
متن کاملEnvironmental stress alters genetic regulation of novelty seeking in vervet monkeys
Considerable attention has been paid to identifying genetic influences and gene-environment interactions that increase vulnerability to environmental stressors, with promising but inconsistent results. A nonhuman primate model is presented here that allows assessment of genetic influences in response to a stressful life event for a behavioural trait with relevance for psychopathology. Genetic a...
متن کاملStress during Adolescence Increases Novelty Seeking and Risk-Taking Behavior in Male and Female Rats
Adolescence is a period of major physical, hormonal, and psychological change. It is also characterized by a significant increase in the incidence of psychopathologies and this increase is gender-specific. Likewise, stress during adolescence is associated with the development of psychiatric disorders later in life. Previously, using a rat model of psychogenic stress (exposure to predator odor f...
متن کاملGhrelin Influences Novelty Seeking Behavior in Rodents and Men
Recent discoveries indicate an important role for ghrelin in drug and alcohol reward and an ability of ghrelin to regulate mesolimbic dopamine activity. The role of dopamine in novelty seeking, and the association between this trait and drug and alcohol abuse, led us to hypothesize that ghrelin may influence novelty seeking behavior. To test this possibility we applied several complementary rod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychoneuroendocrinology
سال: 2007
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2007.05.008